It comes amid heightened tensions with the Iraqi government and Iran.
A ceremony will take place this week at al-Qaim, where the US will formally hand over equipment to the Iraqi army to help it ensure security in the area.
It will end any US presence along the Iraqi side of the border with Syria.
The base is built on the ruins of one the Iraq’s oldest train stations, near a tiny town of the same name along the Euphrates river.
The area was the first place in Iraq to fall into the hands of the Islamic State group (IS) in 2014 and one of the last taken back by Iraqi forces in November 2017.
After the victory against IS in the area, Iranian-backed militia groups took control of both sides of the border.
Although Iraqi security forces have also had a presence around al-Qaim, it is now mainly under the control of…