At least 221 people were killed, including 127 civilians, the Syrian Observatory for Human Rights said.
The Syrian Observatory for Human Rights said the attacks hit several areas of the largely government-held southern province of Sweida, where ISIS retains a presence in a northeastern desert region.
The bloodshed came almost a week into a Russia-backed regime campaign to oust ISIS fighters from a holdout in a neighbouring province of the country’s south.
ISIS claimed responsibility for the violence, saying “soldiers of the caliphate” attacked Syrian government positions and security outposts in Sweida city, then detonated explosive belts.
The Britain-based Observatory said four suicide bombers targeted Sweida city while others hit small villages to the north and east and shot residents in their homes.
At least 221 people were killed, including 127 civilians, the Observatory said.
The remaining 94 dead were pro-regime fighters, mostly residents who took up arms to defend their homes, it said.
The overwhelming majority of the dead “were in (Sweida’s) northern countryside, where the bodies of civilians executed inside their homes were found,” Observatory head Rami Abdel Rahman told AFP.
Sweida, whose residents are mostly from the Druze minority, has been relatively insulated…